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iRiBio team
Hervé SEZNEC is a researcher at CNRS / IN2P3. Head of the iRiBio team, Hervé Seznec is dedicated to the development and implementation of physical methods using ion microbeams in order to adress fundamental and applied questions in the field of life sciences. He develops multi-modal and multiscale approaches in order to obtain qualitative, quantitative, dynamic and real-time molecular and cellular data at the individual and population level.
As a biologist (PhD in Biology and Molecular Genetics), he uses biological models like Caenorhabditis elegans to study precisely the molecular and cellular mechanisms induced by physical stresses (ionizing radiation, nanoparticles of metal oxides). Today, his research is based on a close combination of cellular and molecular biology methods and on the strong technical potential of these instruments in particle physics (ion microbeam) to characterize the biological responses induced by low doses of exposure to ionizing radiation (micro-irradiation controlled at the subcellular scale) and / or exposures to nanoparticles of metal oxides (quantitative and multi-modal micro-analysis). His research falls within the following fields of application: (i) knowledge of the fundamental mechanisms involved in maintaining the integrity of genomes; (ii) molecular and cellular radiobiology; (iii) correlative and multi-modal microscopy; (iv) new anti-cancer therapeutic approaches (proton therapy, nanomedicine). |
Dr Hervé SeznecHead of the iRiBio groupCNRS researcher - HDR CENBG - iRiBio Chemin du solarium CS10120 - 33175 Gradignan cedex Tel: +33 (0)557 120 864 Email: seznech at cenbg.in2p3.fr |
ExpertiseCell and molecular biology (transfection, QRTPCR, ...), microbiology (Caenorhabditis elegans), real-time video microscopy, confocal microscopy, ion beam microanalysis, correlative microscopyKeywords: DNA repair, cellular and molecular radiobiology, nanomedicine, nanotoxicology, microscopy, Caenorhabditis elegans | |
As part of the interdisciplinary research programs of the iRiBio group, Philippe Barberet is dedicated to the development of experimental tools (ion microbeams) and numerical tools (Monte-Carlo simulations) derived from nuclear instrumentation and applied to life sciences. As a physicist, P. Barberet joined the team in 2006 after a doctorate at CENBG (2000-2003) and two years of post-doctoral studies at GSI Darmstadt in Germany (2004-2006). P. Barberet is particularly involved in the development of the focused beamlines of the AIFIRA platform. These experimental methods of targeted micro-irradiation and elemental micro-analysis are used to characterize radiation-induced biological responses at the cellular level and the impact of exposure to nanoparticles of metal oxides on the living.
ExpertiseIon microbeams, accelerators, nuclear instrumentation, microscopy, elemental microanalysis, Monte Carlo simulations (Geant4), diamond detectors |
Dr Philippe BarberetAssociate professor, Bordeaux universityScientific coordinator of AIFIRA facility CENBG - iRiBio Chemin du solarium CS10120 - 33175 Gradignan cedex Tel: +33 (0)557 120 903 Email: barberet at cenbg.in2p3.fr |
TeachingHead of the Master of Engineering in Physics: Radiation and Instrumentation"Courses, tutorials and practical work in physics and physics-chemistry at Bordeaux University. | |
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Dr Guillaume DevèsResearch engineerCENBG - iRiBio Chemin du solarium CS10120 - 33175 Gradignan cedex Tel: +33 (0)557 120 903 Email: deves at cenbg.in2p3.fr |
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Dr Sébastien IncertiCNRS research directorSpokesman of the Geant4-DNA collaboration Director of the International French Korean laboratory FKPPL Member of CoNRS, section 01 Associate editor ofEuropean Journal of Medical Physics - Physica Medica / Elsevier CENBG - iRiBio |
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Dr Claire MicheletAssociate Professor, Bordeaux University Head of the Master 2 Pro Nuclear InstrumentationCENBG - iRiBio Chemin du solarium CS10120 - 33175 Gradignan cedex Tel: +33 (0)557 120 864 Email: michelet at cenbg.in2p3.fr |
With Master degree in Medical Physics from Paul Sabatier University (Toulouse III), Eva TORFEH joined the iRIBIO group in November 2016 for her PhD in Physics at the University of Bordeaux (Graduate School of Physics and Physics engineering, PhD supervisor Philippe BARBERET). As part of the radiobiology studies carried out within the iRiBio group, Eva Torfeh’s thesis project aims to define and precisely characterize the dosimetry at the cellular level and the different physical parameters for experimental irradiations on human cells (in vitro) and on a living organism "C.elegans" (in vivo). Eva Torfeh is developing micro-dosimetric models in order to define different physical observables: local dose, energy deposits, secondary particle spectra, trace structure, etc ... The interest is to to be able to correlate these numerical simulations with the biological responses observed following the irradiations. These simulations are performed using the Monte Carlo Geant4 tool and its extension for micro-dosimetry Geant4-DNA).
ExpertiseMonte-Carlo Simulation (Geant4 et Geant4-DNA), confocal microscopy et image processing (ImageJ), culture and maintenance of C.elegans, data processing (Python) |
Eva TorfehPhD studentCENBG - iRiBio Chemin du solarium CS10120 - 33175 Gradignan cedex Tel: +33 (0)557 120 864 Email: torfeh at cenbg.in2p3.fr |
| Wook Geun Shin is a doctoral student in co-supervision between the University of Bordeaux and the University of Yonsei in South Korea (2017-2020). Its activity focuses on the development of new physical models for Geant4-DNA and the extension of Geant4-DNA for the modeling of early and late biological damage. He is a member of the France-South Korea FKPPL Associated International Laboratory. | Wook-Geun ShinPhD studentCENBG - iRiBio Chemin du solarium CS10120 - 33175 Gradignan cedex Tel: +33 (0)557 120 889 Email: shin at cenbg.in2p3.fr |
Dr Franck GobetProfessorDirector of the Physics and Engineering doctoral school CENBG - iRiBio Chemin du solarium CS10120 - 33175 Gradignan cedex Tel: +33 (0)557 120 876 Email: gobet at cenbg.in2p3.fr |
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Dr Philippe MorettoDirecteur du CENBGProfesseur Email: moretto at cenbg.in2p3.fr |
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