CNRS Université Bordeaux

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Context. Living organisms are constantly exposed in their environment to low doses of ionizing radiation (IR). However, although the biological effects induced by IR are well known at high doses, the radiation-induced effects at low doses remain a scientific question.

Objectives The objective of this project is to characterize the radio-induced biological consequences and their transmission following controlled radiological exposures in terms of dose at the organism level. The originality of this project is based on the combination of the use of Monte Carlo code (Geant4) and nuclear microprobes (micro-irradiation) applied to a reference organism C. elegans, which offers the opportunity to understand the radio-induced consequences on RNA metabolism: the transcriptome and the epitranscriptome. This project offers the opportunity to study in vivo the "indirect" effects of IR on RNA metabolism as a function of dose. This project aims at answering the following questions: what are the effects induced through the "indirect" effects of IRs on RNA metabolism? In addition to changes in transcription profiles/levels, are there specific radiation-induced alterations such as chemical base modifications, "editing", splicing alterations, expression of particular RNAs? Is there a relationship between exposure dose (at low doses) and response time to damage? Are there differences in sensitivity between different cell types? Is there a threshold below which no biological effects are detectable or can effects still be detected that are moderate enough for cellular mechanisms to restore normal homeostasis? Do these different types of effects persist and are they transmissible to subsequent generations?

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  • CNRS 80’Prime


  • D. Dupuy, IECB, INSERM, ARNA
  • AIFIRA facility


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