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CIS - Chemical Imaging and Speciation

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Objectives : to understand the mechanisms of neurobiology and neurotoxicity of chemical elements, stable or radioactive, owing to ion beam and synchrotron radiation imaging and speciation techniques.

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Nano-SXRF images of a postsynaptic compartment from an hippocampal neuron (zinc, red; copper, green)

Research projects

- Role of copper and zinc in synapse formation
- Manganese neurotoxicology
- Uranium neurotoxicology
- Iron and alpha-synuclein in dopamine neurons
- Copper and zinc in superoxide dismutase and amyotrophic lateral sclerosis
- Copper deficit, proteinopathy of superoxide dismutase and Parkinson’s disease

The analytical techniques

Ion beam analysis at AIFIRA facility (CENBG):
- PIXE (Particle Induced X-ray Emission)
- RBS (Rutherford Backscattering Spectrometry)

Synchrotron radiation analysis at ESRFand SOLEIL facilities:
- SXRF (Synchrotron Radiation X-ray Fluorescence)
- XAS (X-ray Absorption Spectroscopy)

CIS team coordinates a special issue on "Neurotoxicity of Environmental Metals":
Open call for articles: Special Issue "Neurotoxicity of Environmental Metal Toxicants"

CIS team is involved in the research consortia:
- GIS French Bio-Inorganic Chemistry French BIC
- GDR Modeling and Instrumentation for Biomedical Imaging GDR Mi2B

Other information.... :