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CIS - Chemical Imaging and Speciation
Objectives : to understand the mechanisms of neurobiology and neurotoxicity of chemical elements, stable or radioactive, owing to ion beam and synchrotron radiation imaging and speciation techniques.
Role of copper and zinc in synapse formation
Manganese neurotoxicology
Uranium neurotoxicology
Iron and alpha-synuclein in dopamine neurons
Copper and zinc in superoxide dismutase and amyotrophic lateral sclerosis
Copper deficit, proteinopathy of superoxide dismutase and Parkinson’s disease
The analytical techniques
Ion beam analysis at AIFIRA facility (CENBG):
PIXE (Particle Induced X-ray Emission)
RBS (Rutherford Backscattering Spectrometry)
Synchrotron radiation analysis at ESRFand SOLEIL facilities:
SXRF (Synchrotron Radiation X-ray Fluorescence)
XAS (X-ray Absorption Spectroscopy)
The CIS team is involved in the research consortia:
GIS French Bio-Inorganic Chemistry French BIC
GDR Modeling and Instrumentation for Biomedical Imaging GDR Mi2B
Other information.... :