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  • Vendredi 19 octobre 2018 11:45-12:00 - Francesco Porcaro - CENBG

    Unravelling uranium neurotoxicity throughout biochemical and imaging approach

    Résumé : Uranium is a ubiquitous element in the environment, resulting in human population exposure to low but unavoidable concentrations from air, water and food. Intake from water and food approximate 0.9-1.5 μg/day. Despite uranium is a radioactive material, its adverse health effects are mainly due to its features as heavy element [1], involving toxic accumulation in kidneys and bones. Regardless the kind and the route of exposure, a small amount of uranium is able to reach the brain, where it can exert neurological effects such as the disruption of the acetylcholine, serotonin, and dopamine systems in animal models [2]. Recently, such neurological effects were also suspected in humans [2].
    In order to mind the gap with human uranium toxicology, since several years our group investigated uranium using both classical cellular biology and chemical imaging approaches on neural cells. During this talk, I will present the best results obtained from the investigation of uranium cellular distribution and citoxicity which allowed to further improve our knowledge on U molecular mechanism of action. In particular, the talk will highlight the result obtained by a correlative optical fluorescence / Synchrotron X-ray Fluorescence Spectroscopy (S-XRF) and Particle Induced X-ray Emission (PIXE) microscopy approaches developed in our laboratory [3,4]. Such method allows a fine uranium detection inside organelles and/ or proteins.
    1. Keith S., Faroon O., Roney N., Scinicariello F., Wilbur S., Ingerman L., Llados F., Plewak D., Wohlers D., Diamond, G., U.S. department of health and human services, Agency for Toxic Substances and Disease Registry. 2013
    2. Dinocourt C., Legrand M., Dublineau I., Lestaevel P., Toxicology 2015, 337, 58-71.
    3. Perrin, L., Carmona, A., Roudeau, S., Ortega, R. 2015 . J. Anal. Atom. Spectrom. 30, 2525-2532.
    4. Roudeau S., Carmona A., Perrin L., Ortega R., Anal. Bioanal. Chem 2014, 406, 6979–6991.

    Lieu : Salle des séminaires, CENBG

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