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iRiBio team

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Hervé SEZNEC is a researcher at CNRS / IN2P3. Head of the iRiBio team, Hervé Seznec is dedicated to the development and implementation of physical methods using ion microbeams in order to adress fundamental and applied questions in the field of life sciences. He develops multi-modal and multiscale approaches in order to obtain qualitative, quantitative, dynamic and real-time molecular and cellular data at the individual and population level.

As a biologist (PhD in Biology and Molecular Genetics), he uses biological models like Caenorhabditis elegans to study precisely the molecular and cellular mechanisms induced by physical stresses (ionizing radiation, nanoparticles of metal oxides). Today, his research is based on a close combination of cellular and molecular biology methods and on the strong technical potential of these instruments in particle physics (ion microbeam) to characterize the biological responses induced by low doses of exposure to ionizing radiation (micro-irradiation controlled at the subcellular scale) and / or exposures to nanoparticles of metal oxides (quantitative and multi-modal micro-analysis).

His research falls within the following fields of application: (i) knowledge of the fundamental mechanisms involved in maintaining the integrity of genomes; (ii) molecular and cellular radiobiology; (iii) correlative and multi-modal microscopy; (iv) new anti-cancer therapeutic approaches (proton therapy, nanomedicine).
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Dr Hervé Seznec

Head of the iRiBio group
CNRS researcher - HDR

CENBG - iRiBio
Chemin du solarium
CS10120 - 33175 Gradignan cedex
Tel: +33 (0)557 120 864
Email: seznech at cenbg.in2p3.fr

Expertise

Cell and molecular biology (transfection, QRTPCR, ...), microbiology (Caenorhabditis elegans), real-time video microscopy, confocal microscopy, ion beam microanalysis, correlative microscopy

Keywords

: DNA repair, cellular and molecular radiobiology, nanomedicine, nanotoxicology, microscopy, Caenorhabditis elegans
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As part of the interdisciplinary research programs of the iRiBio group, Philippe Barberet is dedicated to the development of experimental tools (ion microbeams) and numerical tools (Monte-Carlo simulations) derived from nuclear instrumentation and applied to life sciences. As a physicist, P. Barberet joined the team in 2006 after a doctorate at CENBG (2000-2003) and two years of post-doctoral studies at GSI Darmstadt in Germany (2004-2006). P. Barberet is particularly involved in the development of the focused beamlines of the AIFIRA platform. These experimental methods of targeted micro-irradiation and elemental micro-analysis are used to characterize radiation-induced biological responses at the cellular level and the impact of exposure to nanoparticles of metal oxides on the living.

Expertise

Ion microbeams, accelerators, nuclear instrumentation, microscopy, elemental microanalysis, Monte Carlo simulations (Geant4), diamond detectors
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Dr Philippe Barberet

Associate professor, Bordeaux university

CENBG - iRiBio
Chemin du solarium
CS10120 - 33175 Gradignan cedex
Tel: +33 (0)557 120 903
Email: barberet at cenbg.in2p3.fr

Teaching

Head of the Master of Engineering in Physics: Radiation and Instrumentation" Board Member of the Physics Training Unit Courses, tutorials and practical work in physics and physics-chemistry at Bordeaux University.
Courses and experimental work in master of physics and master "Materials of Cultural Heritage and Archeometry" (University Bordeaux-Montaigne): nuclear physics, ion beam analysis, radiation-matter interaction, medical nuclear physics, data acquisition, projects in instrumentation.
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Expertise

  • Ion beam analysis PIXE, STIM, RBS
  • Chemical imaging by µ-XRF and synchrotron x-ray fluorescence
  • Chemical element speciation using XANES, EXAFS
  • Epi-fluorescence microscopy and confocal microscopy
  • Statistics and Data analysis

Curriculum

  • PhD in analytical chemistry and environment - University of Bordeaux (2010)
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Dr Guillaume Devès

Research engineer

CENBG - iRiBio
Chemin du solarium
CS10120 - 33175 Gradignan cedex
Tel: +33 (0)557 120 903
Email: deves at cenbg.in2p3.fr
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Expertise


  • Extension of Geant4 as part of the Geant4-DNA project for the modeling of direct and indirect early damage caused by ionizing radiation.
  • Modeling of realistic cellular geometries based on 3D confocal imaging
  • Modeling of specific radiative environments (eg aboard the International Space Station, on the surface of the planet Mars) for the development of biochips for the search for traces of life in the solar system. Participation in associated irradiation campaigns.
  • Beam optics with high focusing power
  • Leader of the development of low energy electromagnetic physics at Geant4.
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    Dr Sébastien Incerti

    CNRS research director
    Spokesman of the Geant4-DNA collaboration
    Director of the International French Korean laboratory FKPPL
    Member of CoNRS, section 01
    Associate editor ofEuropean Journal of Medical Physics - Physica Medica / Elsevier

    CENBG - iRiBio
    Chemin du solarium
    CS10120 - 33175 Gradignan cedex
    Tel: +33 (0)557 120 889
    Email: incerti at cenbg.in2p3.fr

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    Expertise

    • Development of STIM and PIXE tomography techniques
    • Procedures for viewing and processing 3D data
    • 3D quantitative analysis

    Dr Claire Michelet

    Associate Professor, Bordeaux University Head of the Master 2 Pro Nuclear Instrumentation

    CENBG - iRiBio
    Chemin du solarium
    CS10120 - 33175 Gradignan cedex
    Tel: +33 (0)557 120 864
    Email: michelet at cenbg.in2p3.fr
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    With Master degree in Medical Physics from Paul Sabatier University (Toulouse III), Eva TORFEH joined the iRIBIO group in November 2016 for her PhD in Physics at the University of Bordeaux (Graduate School of Physics and Physics engineering, PhD supervisor Philippe BARBERET). As part of the radiobiology studies carried out within the iRiBio group, Eva Torfeh’s thesis project aims to define and precisely characterize the dosimetry at the cellular level and the different physical parameters for experimental irradiations on human cells (in vitro) and on a living organism "C.elegans" (in vivo). Eva Torfeh is developing micro-dosimetric models in order to define different physical observables: local dose, energy deposits, secondary particle spectra, trace structure, etc ... The interest is to to be able to correlate these numerical simulations with the biological responses observed following the irradiations. These simulations are performed using the Monte Carlo Geant4 tool and its extension for micro-dosimetry Geant4-DNA).

    Expertise

    Monte-Carlo Simulation (Geant4 et Geant4-DNA), confocal microscopy et image processing (ImageJ), culture and maintenance of C.elegans, data processing (Python)
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    Eva Torfeh

    PhD student

    CENBG - iRiBio
    Chemin du solarium
    CS10120 - 33175 Gradignan cedex
    Tel: +33 (0)557 120 864
    Email: torfeh at cenbg.in2p3.fr
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    Wook Geun Shin is a doctoral student in co-supervision between the University of Bordeaux and the University of Yonsei in South Korea (2017-2020). Its activity focuses on the development of new physical models for Geant4-DNA and the extension of Geant4-DNA for the modeling of early and late biological damage. He is a member of the France-South Korea FKPPL Associated International Laboratory.
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    Wook-Geun Shin

    PhD student

    CENBG - iRiBio
    Chemin du solarium
    CS10120 - 33175 Gradignan cedex
    Tel: +33 (0)557 120 889
    Email: shin at cenbg.in2p3.fr
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    Dr Franck Gobet

    Professor
    Director of the Physics and Engineering doctoral school

    CENBG - iRiBio
    Chemin du solarium
    CS10120 - 33175 Gradignan cedex
    Tel: +33 (0)557 120 876
    Email: gobet at cenbg.in2p3.fr
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    Dr Philippe Moretto

    Directeur du CENBG
    Professeur

    Email: moretto at cenbg.in2p3.fr
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