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Accueil du site > ANGLAIS > Research > iRiBio > Nanoparticles and microprobe analysis


Nanoparticles and microprobe analysis

Since many years, Nanoscience has been promising remarkable progresses in many areas, but also raises many concerns about its impact on human health. Among other things, the question is posed of the detection, quantification and fate of nanoparticles in biological organisms. It is therefore essential to specify the mechanisms involved in these internalization and toxicity processes and to characterize them within in vitro / in vivo biological models. Thus, we develop and implement quantitative analysis methods by combining highly resolving imaging techniques (confocal and electronic microscopy, 2D and 3D ion beam analysis) to characterize:

  • the accumulation and intracellular distribution of nanoparticles (titanium dioxides) native or functionalized with fluorescent agents (FITC, Rhodamine)
  • the toxicology of these manufactured nanoparticles
  • their fate during development within a biological model of interest (human epithelial and endothelial cells, c. elegans).
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    Fundings

    • ANR CES TITANIUMS
    • CNRS IN2P3
    • University of Bordeaux
    • Région Aquitaine

    Collaborations

    • M.-H. Delville, ICMCB
    • E. Chevet, INSERM ERL440, "Oncogenesis Stress Signaling", Université de Rennes
    • D. Dupuy, INSERM U869, IECB, Laboratoire ARNA
    • Projet Région Aquitaine ToxNano
    • Plateforme Génomique Fonctionnelle de Bordeaux
    • Plateforme AIFIRA

    Contacts

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