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Accueil du site > ANGLAIS > Research > iRiBio > Cancer and cellular micro-irradiation


Cancer and cellular micro-irradiation

The objective of this theme is to define the impact of exposure to controlled doses of ionizing radiation on living organisms (evolution / genome). To date, the understanding of the molecular mechanisms involved in the relationships between DNA-induced damage, repair, and radioresistance / radiosensitivity phenomena remains limited. For this purpose, we propose

  • to expose biological models of interest (human epithelial and endothelial cells, C. elegans) in controlled radiative environments (ion microbeam, Clinac ...)
  • to study the nuclear and chromatin metabolism as well as the repair of these damages using video-microscopy and confocal microscopy
  • to define the impact of these exposures on genome expression by cytogenetics and genomic analysis

  • The dynamic and kinetic integration of parameters such as the nature of the damage, its detection, its repair and the molecular and cellular consequences in the early and later phases (genome / evolution) of the response to irradiation could be performed according to the type of particles (alpha, proton) or irradiation dose from both a qualitative and a quantitative point of view.
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    Fundings

    • ANR Geant4-DNA
    • IN2P3
    • University of Bordeaux
    • Région Aquitaine
    • FP7 SPIRIT

    Collaborations

    • D. Dupuy - AVENIR/Evolution des génomes- INSERM, IECB, PESSAC
    • G. Kantor, F. Chibon - Institut Bergonié, Bordeaux
    • Plateforme Génomique Fonctionnelle Bordeaux
    • Plateforme AIFIRA

    Contacts

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