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Research projects

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Metals and neurodegerative diseases
- subcellular imaging and speciation of metals in neurons
- speciation of metalloproteins
- copper homeostasis in Parkinson’s disesae

Nuclear Toxicology: toxic effects of elements used in nuclear industry and research
- soluble cobalt
- cobalt oxide
- uranium

Pulmonary toxicity of cobalt oxide particles : a Trojan-horse mechanism

In case of internal contamination in nuclear power plants, the isotope most frequently found among workers is 60Co from Co oxide particles. The lung is the critical organ, most of the time after exposure by inhalation of contaminated vapors. The purpose of this study conducted in collaboration with CEA teams within the frame of the Nuclear Toxicology Program (ToxNuc) was to describe the chemical mechanisms of cobalt toxicity either in soluble form or as oxide, on human lung cells. Cobalt (...)

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Neuron imaging and manganese speciation

Environmental exposure to neurotoxic metals such as manganese could be one of the risk factors causing Parkinson’s disease. Organometallic manganese compounds are used as pesticides (Maneb), or as additives in unleaded gasoline (MMT). Using micro-SXRF methods (Synchrotron X -Ray Fluorescence) and micro-XAS (X -ray Absorption Spectroscopy) at the ESRF (European Synchrotron Radiation Facility), we highlighted the accumulation of manganese in the Golgi apparatus of dopaminergic cells (...)

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