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Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson’s disease brain

Trist B.G., Davies K.M., Cottam V., Genoud S., Ortega R., Roudeau S., Carmona A., De Silva K., Wasinger V., Lewis S.J.G., Sachdev P., Smith B., Troakes C., Vance C., Shaw C., Al-Sarraj S., Ball H.J., Halliday G.M., Hare D.J., Double K.L. (2017), Acta Neuropathologica, 134, 113-127. [pubmed] [link]

Zinc and copper effects on stability of tubulin and actin networks in dendrites and spines of hippocampal neurons

Perrin L., Roudeau S., Carmona A., Domart F., Petersen J.D., Bohic S., Yang Y., Cloetens P., Ortega R. (2017), ACS Chemical Neuroscience, just accepted manuscript. [pubmed] [link]

Heterogeneous intratumoral distribution of gadolinium nanoparticles within U87 human glioblastoma xenografts unveiled by micro-PIXE imaging

Carmona A., Roudeau S., L’Homel B., Pouzoulet F., Bonnet-Boissinot S., Prezado Y., Ortega R. (2017), Analytical Biochemistry, 523, 50-57. [pubmed] [link]

An Akouemma hemisphaeria organic macrofossils colony hosting biodiversity assemblage on the seafloor of Okondja Basin (Gabon) dated at 2.2 Ga

Edou-Minko A., Moussavou M., Sato T., Tchikoundzi C., Sawaki Y., Ndong Ondo S., Ortega R., Maire R., Kaestner A., Mbina Mounguengui M., Roudeau S., Fleury G., Carmona A., de Parseval Ph., Mvoubou M., Moussavou B.M., Agondjo M.O., Sasaki O., Maruyama S. (2017), Journal of Geology and Geophysics, 6, 281. [link]


Evidence of isotopic fractionation of natural uranium in cultured human cells

Paredes E., Avazeri E., Malard V., Vidaud C., Reiller P., Ortega R., Nonell A., Isnard H., Chartier F., Bresson C. (2016), Proc. Natl. Acad. Sci. USA., 113, 14007-14012. [pubmed] [link]

α-Synuclein over-expression induces increased iron accumulation and redistribution in iron-exposed neurons

Ortega R., Carmona A., Roudeau S., Perrin L., Dučić T., Carboni E., Bohic S., Cloetens P., Lingor P. (2016), Molecular Neurobiology, 53, 1925-1934. [pubmed] [link]

Overview of chemical imaging methods to address biological questions
Menezes Lyra da Cunha M., Trepout S., Messaoudi C., Wu T-D, Ortega R., Guerquin-Kern J-L., Marco S. (2016),  Micron, 84, 23-36. [pubmed] [link]

Sod1 aggregation : A pathological link between Parkinson’s disease and amyotrophic lateral sclerosis ?

Trist B.G., Davies K.M., Genoud S., Smoothy V., Halliday G.M., Roudeau S., Carmona A., Perrin-Verdugier L., Ortega R., Double K.L. (2016), Movement Disorders, 31, S241-S242. [link]


Evaluation of sample preparation methods for single cell quantitative elemental imaging using proton or synchrotron radiation focused beams
Perrin L., Carmona A., Roudeau S., Ortega R. (2015),  Journal of Analytical Atomic Spectrometry, 30, 2525-2532. [link]

Reduced net charge and heterogeneity of pI isoforms in familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase
Roudeau S, Chevreux S, Carmona A, Ortega R. (2015), Electrophoresis, 36, 2482-2488. [pubmed] [link]

Multicellular Consortia Preserved in Biogenic Ductile-Plastic Nodules of Okondja Basin (Gabon) by 2.1 Ga
Moussavou M., Edou-Minko A., Mbina Mounguengui M., Ortega R., Fleury G., Roudeau S., Carmona A., Genty D., Blamart D., Tchikoundzi C., Makaya Mvoubou., Musavu Moussavou B., Ndong Ondo., Ogandaga Agondjo M., Dewilde F., Delorme G., de Parseval Ph., Weil R., Maire R. (2015), Journal of Geology & Geophysics, 4:195. [link]

Analysis of platinum and trace metals in treated glioma rat cells by X-ray fluorescence emission
Gil S., Carmona A., Martínez-Criado G., León A., Prezado Y., Sabés M. (2015), Biological Trace Element Research, 163, 177-183. [pubmed] [link]


Correlative organelle fluorescence microscopy and synchrotron X-ray chemical element imaging in single cells
Roudeau S., Carmona A., Perrin L., Ortega R. (2014), Analytical and Bioanalytical Chemistry, 406, 6979-6991. [pubmed] [link]

Low-solubility particles and a Trojan-horse type mechanism of toxicity : the case of cobalt oxide on human lung cells
Ortega R., Bresson C., Darolles C., Gautier C., Roudeau S., Perrin L., Janin M., Floriani M., Aloin V., Carmona A., Malard V. (2014), Particle & Fibre Toxicology, 11:14. [pubmed] [link]

Stratigraphic analysis of the Sterkfontein StW 573 Australopithecus skeleton and implications for its age
Bruxelles L., Clarke R.J., Maire R., Ortega R., Stratford D. (2014), Journal of Human Evolution, 70, 36-48. [link]

Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells : relationship between speciation, subcellular distribution, and cytotoxicity
Carmona A., Roudeau S., Perrin L., Veronesi G., Ortega R. (2014), Metallomics, 6, 822-832. [pubmed] [link]

Copper pathology in vulnerable brain regions in Parkinson’s disease
Davies K.M., Bohic S., Carmona A., Ortega R., Cottam V., Hare D.J., Finberg J.P.M., Reyes S., Halliday G.M., Mercer J.F.B, Double K.L., (2014), Neurobiology of Ageing, 35, 858-866. [pubmed] [link]

Improvement and recent applications of the Tohoku microbeam system
Matsuyama S., Ishii K., Watanabe K., Terakawa A., Kikuchi Y., Fujiwara M., Sugai H., Karahashi M., Nozawa Y., Yamauchi S., Fujisawa M., Ishiya M., Nagaya T., Ortega R., Carmona A., Roudeau S. (2014), Nuclear Instruments and Methods in Physics Research B, 318, 32-36. [link]


Analytical tools for speciation in the field of toxicology
Bresson C., Chartier F., Ansoborlo E., Ortega R. (2013) . Radiochimica Acta, 101, 349-357. [link]

Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and synergistic toxicity with zinc
Bresson C., Darolles C., Carmona A., Gautier C., Sage N., Roudeau S., Ortega R., Ansoborlo E., Malard V. (2013), Metallomics, 5, 133-143. [pubmed] [link]


Study of radiation effects on the cell structure and evaluation of a dose delivered by X-ray and alpha-particles microscopy
Kosior E., Cloetens P., Devès G., Ortega R., Bohic S. (2012), Applied Physics Letters, 101, 263102 [link]

X-ray absorption spectroscopy of biological samples. A tutorial
Ortega R., Carmona A., Llorens I., Solari P.L. (2012), Journal of Analytical Atomic Spectrometry, 27, 2054-2065 [link]

Special issue on toxicology of pesticides
Sanchez-Bayo F., Ortega R. (2012), Journal of Environmental Analytical Toxicology, S4-e001 [link]

High spatial resolution chemical imaging of inorganic and organometallic pesticides
Ortega R., Carmona A. (2012), Journal of Environmental Analytical Toxicology, S4-005 [link]

Micro-PIXE for single cell analysis
Ortega R. (2012), International Journal of PIXE, 22, 51-56 [link]

Coupling of native IEF and Extended X-ray Absorption Fine Structure to characterize zinc binding sites from pI isoforms of SOD1 and A4V pathogenic mutant
Chevreux S., Llorens I., Solari P.-L., Roudeau S., Devès G., Carmona A., Testemale D., Hazemann J.L., Ortega R. (2012), Electrophoresis, 33, 1276-1281 [pubmed] [link]

Combined use of hard X-ray phase contrast imaging and X-ray fluorescence microscopy for subcellular metal quantification
Kosior E., Bohic S., Suhonen H., Ortega R., Devès G., Carmona A., Marchi F., Guillet J.F., Cloetens P. (2012), Journal of Structural Biology, 177, 239-247. [pubmed] [link]

Chemical element imaging for speleothem geochemistry : Application to an uranium-bearing corallite with aragonite diagenesis to opal (Eastern Siberia, Russia)
Devès G., Perroux A.-S., Bacquart T., Plaisir C., Rose,J., Jaillet S., Ghaleb B., Ortega R., Maire R. (2012) , Chemical Geology, 294-295, 190-202 [link]


Morphosedimentary study of a cave deposit at Bois du Clos cave (Charente, France) : geometric constraints and hydrological dynamics
Dandurand G., Devès G., Maire M., Ortega R., Genty D, Ghaleb B. (2011), Quaternaire, 22, 285-306. [link]

The plant cell nucleolus as a hot spot for iron
Roschzttardtz H., Grillet L., Isaure M.P., Conéjéro G., Ortega R., Curie C., Mari S. (2011), The Journal of Biological Chemistry, 286, 27863-27866. [pubmed] [link]

First quantitative imaging of organic fluorine within angiogenic tissues by Particle Induced Gamma-Ray Emission (PIGE) analysis : first PIGE organic fluorine imaging
Lavielle S., Gionnet K., Ortega R., Devès G., Kilarski V., Wehbe K., Bikfalvi A., Déléris G. (2011), Pharmaceutics, 3, 88-106. [pubmed] [link]

Direct speciation analysis of inorganic elements in single cells using X-ray absorption spectroscopy
Ortega R. (2011), Journal of Analytical Atomic Spectrometry, 26, 23-29. [link]

X-ray fluorescence microchemical analysis and autoradiography applied to cave deposits : speleothems, detrital rhythmites, ice and prehistoric paintings
Dandurand G., Maire M., Ortega R., Devès G., Lans B., Morel L., Perroux A.-S., Vanara N., Bruxelles L., Jaillet S., Billy I., Martinez P., Ghaleb B, Valla F. (2011), Géomorphologie : relief, processus, environnement, 4, 407-426. [link]


Manganese accumulates within Golgi apparatus in dopaminergic cells as revealed by synchrotron X-Ray fluorescence nano-imaging
Carmona A., Devès G., Roudeau S., Cloetens P., Bohic S., Ortega R. (2010), ACS Chemical Neurosciences, 1, 194-203. [pubmed] [link]

Direct speciation analysis of arsenic in sub-cellular compartments using micro-X-ray absorption spectroscopy
Bacquart T., Devès G., Ortega R. (2010), Environmental Research, 110, 413-416. [pubmed] [link]


3D imaging of human cells by using PIXE-µ-CT
Kawamura Y., Ishii K., Matsuyama S., Nakhostin M., Fujiwara M., Tsuboi S., Yamanaka K., Watanabe M., Okura S., Hashimoto Y., Fujikawa M., Hatori Y., Hamada N., Fujiki K., Yamazaki H., Ortega R., Deves G., Carmona A. (2009), International Journal of PIXE, 1-2, 29-37. [link]

EXAFS analysis of a human Cu,Zn SOD isoform focused using non-denaturing gel electrophoresis
Chevreux S., Solari P.L., Roudeau S., Devès G., Alliot I.,Testemale J.L., Hazemann J.L. Ortega R. (2009), Journal of Physics IV, 190, 012205. [link]

Multimodal analysis of metals in copper-zinc superoxide dismutase isoforms separated on electrophoresis gels
Chevreux S., Roudeau S., Fraysse A., Carmona A., Devès G., Solari P.-L., Mounicou S., Lobinski R., Ortega R. (2009), Biochimie 91, 1324-1327. [pubmed] [link]

Bio-metals imaging and speciation in cells using proton and synchrotron radiation X-ray micro-spectroscopy
Ortega R., Devès G., Carmona A. (2009), J. R. Soc. Interface 6, S649–S658. [pubmed] [link]

Fluorine micro-imaging and quantification using nuclear reaction analysis : a new tool for tissue distribution validation of positron emission tomography tracers
Devès G., Roudeau S., Carmona A., Lavielle S., Gionnet K., Déléris G., Ortega R. (2009), Applied Physics Letters 95, 023701. [link]

Cobalt distribution in keratinocyte cells indicates nuclear and perinuclear accumulation and interaction with magnesium and zinc homeostasis
Ortega R., Bresson C., Fraysse A., Sandre C., Devès G., Gombert C., Tabarant M., Bleuet P., Seznec H., Simionovici A., Moretto Ph., Moulin C. (2009), Toxicology Letters 188, 26-32. [pubmed] [link]

Synchrotron radiation for direct analysis of metalloproteins on electrophoresis gels
Ortega R. (2009), Metallomics, 1, 137-141. [pubmed] [link]

Public health strategies for Western Bangladesh that address the arsenic, manganese, uranium and other toxic elements in their drinking water
Frisbie S.H., Mitchell E.J., Mastera L.J., Maynard D.M., Zaki Yusuf A., Yusuf Siddiq M., Ortega R., Dunn R.K., Westerman D.S., Bacquart T., Sarkar B. (2009), Environmental Health Perspectives, 117, 410-416. [pubmed] [link]


Direct speciation of metals in copper-zinc superoxide dismutase isoforms on electrophoresis gels using X-ray absorption near edge structure
Chevreux S., Roudeau S., Fraysse A., Carmona A., Devès G., Solari P.L., Weng T.C., Ortega R. (2008), Journal of Analytical Atomic Spectrometry, 23, 1117-1120. [link]

Nano-imaging of trace metals by synchrotron X-ray fluorescence into dopaminergic single cells and neurite-like processes
Carmona A., Cloetens P., Devès G., Bohic S., Ortega R. (2008), Journal of Analytical Atomic Spectrometry, 23, 1083-1088. [link]

Development of analytical procedures for the determination of hexavalent chromium in corrosion prevention coatings used in the automotive industry
Séby F., Castetbon A., Ortega R., Guimon C., Niveau F., Barrois-Oudin N., Garraud H., Donard O.F. (2008), Analytical Bioanalytical Chemistry, 391, 587-597. [pubmed] [link]

Quantitative micro-analysis of metal ions in subcellular compartments of cultured dopaminergic cells by combination of three ion beam techniques
Carmona A., Devès G., Ortega R. (2008), Analytical Bioanalytical Chemistry, 390, 1585-1594. [pubmed] [link]

Micro-chemical imaging of iodine distribution in the brown alga Laminaria digitata suggests a new mechanism for its accumulation
Verhaeghe E., Fraysse A., Guerquin-Kern J-L., Wu T.D., Devès G., Mioskowski C., Leblanc C., Ortega R., Ambroise Y., Potin P. (2008), Journal of Biological Inorganic Chemistry, 13, 257-269. [pubmed] [link]


Iron storage in neurovesicles revealed by chemical nano-imaging
Ortega R., Cloetens P., Devès G., Carmona A., Bohic S. (2007), PLoS ONE, 2(9), e925. [pubmed] [link]

Subcellular speciation analysis of trace element oxidation states using synchrotron radiation micro-X-ray absorption near edge structure
Bacquart T., Devès G., Carmona A., Tucoulou R., Bohic S., Ortega R. (2007), Analytical Chemistry, 79, 7353-7359. [pubmed] [link]