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CIS - Chemical Imaging and Speciation

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Objectives : to describe the mechanisms of toxicity of chemical elements, stable or radioactive, owing to ion beam and synchrotron radiation imaging and speciation techniques at the cell or tissue levels.

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Nano-SXRF images of a postsynaptic compartment from an hippocampal neuron (zinc, red; copper, green)

Research projects

Metals and neurodegerative diseases : neuronal imaging and speciation of metalloproteins
- imaging and speciation of metals in neurons
- Cu and Zn speciation in superoxide dismutase in amyotrophic lateral sclerosis
- copper homeostasis in Parkinson’s disease

Nuclear Toxicology: investigation of toxicity mechanisms of chemical elements used in nuclear industry and research
- soluble cobalt
- cobalt oxide particles
- uranium

The analytical techniques

Ion beam analysis at AIFIRA facility (CENBG):
- PIXE (Particle Induced X-ray Emission)
- RBS (Rutherford Backscattering Spectrometry)

Synchrotron radiation analysis at ESRFand SOLEIL facilities:
- SXRF (Synchrotron Radiation X-ray Fluorescence)
- XAS (X-ray Absorption Spectroscopy)

Other information.... :