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CIS - Chemical Imaging and Speciation

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Objectives : to describe the mechanisms of toxicity of chemical elements, stable or radioactive, owing to ion beam and synchrotron radiation imaging and speciation techniques at the cell or tissue levels.

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Nano-SXRF images of a postsynaptic compartment from an hippocampal neuron (zinc, red; copper, green)

Research projects

Metals and neurodegenerative diseases: nano-imaging and speciation
- Role of copper and zinc in synaptic plasticity
- Manganese in parkinsonism
- Imaging and speciation of iron in dopamine neurons
- Copper and zinc speciation in superoxide dismutase and amyotrophic lateral sclerosis
- Copper deficit in Parkinson’s disease

Nuclear toxicology: mechanisms of toxicity of chemical elements used in nuclear industry
- Uranium neurotoxicology
- Cobalt oxide particles

The analytical techniques

Ion beam analysis at AIFIRA facility (CENBG):
- PIXE (Particle Induced X-ray Emission)
- RBS (Rutherford Backscattering Spectrometry)

Synchrotron radiation analysis at ESRFand SOLEIL facilities:
- SXRF (Synchrotron Radiation X-ray Fluorescence)
- XAS (X-ray Absorption Spectroscopy)

Other information.... :